The immune system of a person with diabetes kills off useful “beta” cells, but the UT researchers say they have found a way to make other cells in the pancreas perform the necessary work. Their approach, announced earlier this month in the academic journal Current Pharmaceutical Biotechnology, not only would have implications for Type 1, formerly called juvenile diabetes, but also could help treat the far more common Type 2 variety, also known as adult-onset diabetes.
Scientists are trying to figure out how to transplant islet cells and then protect them from the patient’s immune system so that long-term immunosuppressive medications aren’t required. Micro encapsulation is an approach scientists are testing to find out if a special coating to the transplanted islets can help the patient avoid rejection of those islets. These coatings let in nutrients to nourish the cells but prevent your body’s immune system from attacking them.
Why do people develop prediabetes? Prediabetes develops through a combination of factors that are still being investigated. For sure, lifestyle factors (food, exercise, stress, sleep) play a role, but family history and genetics certainly do as well. It is easy to assume that prediabetes is the result of being overweight, but the relationship is not that simple. While obesity is one underlying cause of insulin resistance, many overweight individuals may never develop prediabetes or type 2 diabetes, and a minority of people with prediabetes have never been overweight. To make matters worse, it can be increasingly difficult to make healthy choices in today’s toxic food environment that steers all of us to make the wrong food choices, and there are many factors that can contribute to weight gain in addition to diet.
Sulfonylureas are the most commonly prescribed diabetes medicines. These medicines help your pancreas make insulin. They are inexpensive and have few side effects. There are 3 types of sulfonyureas: glipizide, glimepiride, and glyburide. Side effects may include weight gain and low level of sodium in the blood. Sulfonylureas can be taken alone or with metformin, pioglitazone (a thiazolidinedione), or insulin. If you’re allergic to sulfa, you can’t take a sulfonylurea.
According to the American Diabetes Association, islet transplantation can replace insulin injections and provide more physiological glucose control, but “there are not sufficient donor islets available for all the individuals who need them, and often it takes islets from several donors to transplant one recipient, exacerbating the donor shortage. A major reason for the need for multiple donors is that more than 80% of transplanted islets die within the first week after transplantation. The surviving islets may overwork and gradually die from exhaustion.”
Metformin: The DPP study found that metformin, the safest first-line therapy for type 2 diabetes, may help delay the onset of type 2 diabetes in people with prediabetes. Participants who took the low-cost generic drug had a 31% reduced risk of developing type 2 diabetes compared to the control group (those not on metformin or intensive lifestyle intervention). Again, 15-year follow up data showed that 17% of those on metformin continued to have a significant reduction in type 2 progression. At this time, metformin (or any other medication, for that matter) is not currently FDA approved for prediabetes, and it is sometimes prescribed “off-label” by a healthcare provider. Your healthcare provider can give you more information and determine whether metformin is a good option for you.
For over a decade, Cummings and others have tried to reframe the very concept of bariatric surgery (they prefer “metabolic surgery”). Their work has shown these procedures just don’t change how much food the stomach can fit; they trigger a cascade of metabolic and bodily changes, many of which help people with type 2 diabetes naturally get their blood sugar under control. Some changes even start happening before a patient loses weight, such as higher levels of peptide production in the gut that seem to restore a patient’s sensitivity to insulin.
First, speak with your doctor — you should not start relying on plants or stop your medicines on your own. You’ll need to work closely with your diabetes health-care provider, and you’ll need to do some research and monitor yourself. Still, millions of people are using plant medicines, and a number of them have written to Diabetes Self-Management to tell us that they’re working.
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In-person diabetes prevention programs: The CDC offers a one year long lifestyle change program through its National Diabetes Prevention Program (NDPP) at various locations throughout the US to help participants adopt healthy habits and prevent or delay progression to type 2 diabetes. This program is a major undertaking by the CDC to translate the findings from the DPP study into a real world setting, a significant effort indeed!
Online diabetes prevention programs: The CDC has now given pending recognition status to three digital prevention programs: DPS Health, Noom Health, and Omada Health. These offer the same one year long educational curriculum as the DPP study, but in an online format. Some insurance companies and employers cover these programs, and you can find more information at the links above. These digital versions are excellent options for those who live far away from NDPP locations or who prefer the anonymity and convenience of doing the program online.
Pramlintide is only appropriate for certain people with diabetes who use insulin and are having problems maintaining their blood sugar levels. Because of the potential for severe hypoglycemia with the use of pramlintide is with insulin, adjustments to insulin dosage and more frequent glucose monitoring may be necessary. Insulin and pramlintide should not be mixed in the same syringe.
Greek clover is an annual herb with aromatic seeds having medicinal properties. It is also known as fenugreek, and is largely used in curry. Greek clover has properties to lower down the levels of glucose in the body, which, in turn, controls diabetes. Also, when given in changeable doses of 25 gm to 100 gm on a daily basis, it was found to diminish reactive hyperglycemia in diabetic patients. Furthermore, levels of glucose, serum cholesterol, and triglycerides were also appreciably reduced. Alternatively, one can just stir two teaspoons of Greek clover seeds in powder form in warm milk and consume on a regular basis; it will control the levels of blood sugar and keep diabetes at bay. In case one does not want to have the powder in milk, seeds can be eaten wholly, too.
The ideas contained on this website are for educational purposes only, and are not intended to treat any disease, nor as a substitute for consulting with your physician. All matters regarding your health require medical supervision. The information provided is not intended to serve as health, medical, or other professional advice related to individual situations. No therapeutic or medical claims are either implied or made. No particular results are guaranteed.
Metformin (Glucophage) is a biguanide. Biguanides lower blood glucose levels primarily by decreasing the amount of glucose produced by the liver. Metformin also helps to lower blood glucose levels by making muscle tissue more sensitive to insulin so glucose can be absorbed. It is usually taken two times a day. A side effect of metformin may be diarrhea, but this is improved when the drug is taken with food.
Purdue and the IU School of Medicine collaborated on this patented work through the National Institute of Health T32 Indiana Bioengineering Interdisciplinary Training for Diabetes Research Program. The research was also supported by the National Science Foundation Graduate Research Fellowship; the Indiana University School of Medicine Center for Diabetes and Metabolic Diseases Pilot and Feasibility Program; and donations from the McKinley Family Foundation.
Low glycemic index foods also may be helpful. The glycemic index is a measure of how quickly a food causes a rise in your blood sugar. Foods with a high glycemic index raise your blood sugar quickly. Low glycemic index foods may help you achieve a more stable blood sugar. Foods with a low glycemic index typically are foods that are higher in fiber.
The reason they need it: Their own insulin-producing islet cells, located in the pancreas, aren’t working. Now, scientists across the US are racing to develop effective ways to transplant new islet cells in people with diabetes—an alternative that could make daily life easier and lower risk for insulin side effects like dangerous low blood sugar episodes.
In type I diabetes, insufficient levels of insulin result from the immune system itself attacking the pancreatic beta cells. On the other hand, while beta cell dysfunction varies widely between type II diabetes patients, insulin resistance is a major part of the disease. Restoring the beta cells of the pancreas to health is the treatment approach these two diseases share to some degree.
Beware of claims that seem too good to be true. Look for scientific-based sources of information. The National Diabetes Information Clearinghouse collects resource information for the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Reference Collection, a service of the National Institutes of Health. To learn more about alternative therapies for diabetes treatment, contact the National Center for Complementary and Alternative Medicine Clearinghouse.
I think I may have the link to the original article and will post back here. I am actually going to meet Denise Faustman on 8/13 at 3:00 to learn more about the study It’s a clinical trial that is being held at mass general. I am surprised by the rather negative comments on here. I have lupus and type 1for 32years. I have no complications but lupus puts the same organs at risk as diabetes does. If I can barely take any insulin and have normal ranges without doing barely any work I will try it. I don’t see… Read more »
Glucose in the bloodstream passes through the kidneys, where it can either be excreted or reabsorbed. Sodium-glucose transporter 2 (SGLT2) works in the kidney to reabsorb glucose, and a new class of medication, SGLT2 inhibitors, block this action, causing excess glucose to be eliminated in the urine. Canagliflozin (Invokana), dapagliflozin (Farxiga), and empagliflozin (Jardiance) are SGLT2 inhibitors that have been approved by the FDA to treat type 2 diabetes. Because they increase glucose levels in the urine, side effects can include urinary tract and yeast infections.
Hi, it’s midnight where I am and my family and I have been awake for an hour post intense leg cramps that I got from my obsessive eating disorder making my blood sugar reach extreme levels (rant!). To anyone who is unfamiliar with diabeties: The experience is hell. It is waking up at ungoldy hours from pain in your legs, bladder, sanity. You’re not the same person with erradic blood sugars. It’s sleeping 16 hours a day-unwillingly falling behind in everything. Keeping GALLONS of water near you to drink, and yet still being thirsty. It’s almost been two years for… Read more »
If you google “diabetes cure” you are directed to websites like WebMD and the Mayo Clinic where you find information on diet, exercise, medication, and insulin therapy, but nothing about the cure. This lack of information may have to do with the fact that Americans spend $322 billion a year to treat diabetes, $60 billion a year on weight-loss programs, and $124 billion a year on snack foods. This is about 3% of the US economy! Because so many peoples’ livelihoods are supported by diabetes and its main cause, obesity, the viral effect of people getting cured and telling others is greatly diminished.